What is the best way to handle a difficult boss?

Your question implies several aspects to be considered.

First question: In which way is the boss difficult?

Time Management

Social interaction

workload expectation

business planning

...

Second question:

Did you ever talk to him about the situation? Does he know about it?

Depending on the answer there are several ways to deal with it. 

First of all it is important, that you are seeking a discussion with him to list the important points/questions/concerns in a constructive way.

Secondly, come up with suggestions you think would help to solve the problems.

Third, ask about his opinion and which suggested solution would help to get things moving in the right direction.

If he is a 'leader' and not a 'boss' then you will come quickly to an agreement on the subject.

Hope that helps.