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How to enhance dissolution profile of a poorly water soluble API?

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Question added by Muhammad Fayyaz , Plant Manager , Pearl pharmaceutical
Date Posted: 2017/06/30
venkatarao  polina
by venkatarao polina , Head Of Operations , DEEP C BLUE CO., LTD.

To improve the solubility with nanocrystalization by antisolvent.

Seyyed Amir Siadati
by Seyyed Amir Siadati , Iran , Tofigh Daru Research & Engineering Pharmaceutical Company

1. you could heat (if the heat does not decompose the matter) or ultrasound the sample solution.

2. you could decrease the concentration of the test solution.

3. or if possible, you could reject the solubility test due to certificate, and then say the project manager to make a new "poly morph" (or a powder with smaller crystals) of the matter by recrystallization.

mohammed irfan
by mohammed irfan , senior microbiologist , chandra labs

We have to check its it's solubility on 0.0001N HCl if not then 0.001N HCl,then 0.01 N HCl and finally 0.1N HCl if

jayasutha iyyapaazham
by jayasutha iyyapaazham , medical Auditor , london hospital

SALT FORM OF DRUG,COSOLVENT,SOLID DISPERSION

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