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Peace be upon you, Sir.
Your question is very vague. There is so many angles to answer this from. I hope you will supply more information.
I am assuming that you are asking about chemical reactions, with respect to chemical change.
Hence, from that angle solely, it is a change in the substance as it undergoes a chemical reaction to form another substance(s). It can be reversible or irreversible, pending the reaction kinetics of that particular reaction that the substance is subjected to.
Hope this helps.
Chemical Change is like your life every second you pass can never come back, in same way if we take chemical reaction example, once reactants are converted to products, they can not take previous shape, if it is possible to bring them with same properties then it is not a chemical change.
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