Which is the best help desk software that also support the active directory users?

Spice works is very good especially if you're trying to minimize investment Stay away from Microsoft system center CA service desk is excellent but costly compared to spiceworks

ManageEngine ServiceDesk Plus

ServiceNow is a cloud computing software whereit replaces email, file sharing, running around, texting, and phone calls.

Manage Engine Service Desk pro

Manage Engine Service Desk pro is the best help desk app that is also support windows Active directory.

Spiceworks is a good Help-desk solution, easy to handle, and includes quite a lot of features, assigning tickets to IT staffs, automated emails for ticket (opening comments and closing) to inteded employee's, etc..

ManageEngine ServiceDesk Plus

It offers an integrated package with Incident Management. ServiceDesk Plus provides all that you need to have a full-fledged IT Help Desk and a productive Help Desk 

I use ServiceDesk Plus

but iintensive for ram and pro and you must have last update for java

You can go with Manage Engine ADmanager or Spiceworks. Both are complete ITIL ready. Also having AD administration components & utilities for easily manage your AD network

I found Manageengine Service Desk Plus with Asset Explorer add-in. We can configure it with the active directory and gives more details about the system with Asset Explorer for support like IP address, Computer Name, Remote desktop option etc. 

I suggest Spiceworks.The main feature of Spiceworks’ free version is that it’s self-hosted.

If you don’t need or want that because you prefer the management and backups to be handled elsewhere then you should probably choose another option.

Stand-out features

1. Free regardless of the number of agents
2. LDAP/Active Directory Synchronization
3. Mobile Integration
4. Multi-Site Support
5. Also offers server monitoring services