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What could differential complete blood count ( differential CBC) be effective in Medical diagnosis?

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Question added by Lubna Al-Sharif , Medical Laboratory Technician , Nablus Specailized Hospital
Date Posted: 2013/11/14
mohanad al samarah
by mohanad al samarah , مشرف وطبيب مخبر , محافظة دمشق

We must measure red blood cells  white blood cells platelets and measure mcv mch mchc and have a real reasons to diagnose dieseses by flowmetry apparatus to have a diagram for normal and abnormal

cells

Mohamed  shaheen
by Mohamed shaheen , مدرس كلينيكال باثولوجي , كلية الطب جامعة الأزهر

Complete Blood Count (CBC)

A complete blood count (CBC) gives important information about the kinds and numbers of cells in the blood, especially red blood cells(RBCs), white blood cells(WBCs), and platelets. A CBC helps the doctor check any symptoms, such as weakness, fatigue, or bruising, you may have. A CBC also helps him to diagnose conditions, such as anemia, infection, and many other disorders.

A CBC test usually includes:

White blood cell (WBC, leukocyte) count. WBCs protect the body against infection. If an infection develops, which attack and destroy the bacteria, virus, or other organism causing it. WBCs are bigger than RBCs but fewer in number. When a person has a bacterial infection, the number of WBCs rises very quickly. The number of WBCs is sometimes used to find an infection or to see how the body is dealing with cancer treatment.

WBC differential:

The major types of WBCs are neutrophils, lymphocytes, monocytes, eosinophils, and basophils. Immature neutrophils, are also part of this test. Each type of cell plays a different role in protecting the body. The numbers of each one of these types of WBCs give important information about the immune system. Too many or too few of the different types of WBCs can help find an infection, an allergic or toxic reaction to medicines or chemicals, & many conditions, as leukemia.

Red blood cell (RBC) count:

RBCs carry oxygen from the lungs to the rest of the body. They also carry carbon dioxide back to the lungs so it can be exhaled. If the RBC count is low (anemia), the body may not be getting the oxygen it needs. If the count is too high (a condition called polycythemia), there is a chance that the RBCs will clump together and block tiny blood vessels (capillaries). This also makes it hard for your RBCs to carry oxygen.

Hematocrit (HCT, packed cell volume, PCV). This test measures the amount of space (volume) RBCs take up in the blood. The value is given as a percentage of RBCs in a volume of blood. For example, a hematocrit of38 means that38% of the blood's volume is made of RBCs. Hematocrit and hemoglobin values are the two major tests that show if anemia or polycythemia is present.

Hemoglobin (Hgb). The hemoglobin molecule fills up the RBCs. It carries oxygen & gives the RBCs its red color. The hemoglobin test measures the amount of hemoglobin in blood and is a good measure of the blood's ability to carry oxygen throughout the body.

Red blood cell indices. There are three RBCs indices: mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC). They are measured by a machine and their values come from other measurements in a CBC. The MCV shows the size of the RBCs. The MCH value is the amount of hemoglobin in an average RBCs. The MCHC measures the concentration of hemoglobin in an average RBCs. These numbers help in the diagnosis of different types of anemia. Red cell distribution width (RDW) can also be measured which shows if the cells are all the same or different sizes or shapes.

Platelet (thrombocyte) count: are the smallest type of blood cell. They are important in blood clotting. When bleeding occurs, the platelets swell, clump together, and form a sticky plug that helps stop the bleeding. If there are too few platelets, uncontrolled bleeding may be a problem. If there are too many platelets, there is a chance of a blood clot forming in a blood vessel. Also, platelets may be involved in hardening of the arteries (atherosclerosis).

Mean platelet volume (MPV): measures the average amount (volume) of platelets & is used along with platelet count to diagnose some diseases. If the platelet count is normal, the mean platelet volume can still be too high or too low.

The blood smear test may be done at the same time as a CBC but it is not part of the regular CBC test. In this test, a drop of blood is spread (smeared) on a slide and stained with a special dye. The slide is looked at under a microscope. The number, size, and shape of red blood cells, white blood cells, and platelets are recorded. Blood cells with different shapes or sizes can help diagnose many blood diseases, such as leukemia, malaria, or sickle cell disease.

after a good experience, even when you smear the blood on the slide you would detect abnormalities present.

سعد سماحة
by سعد سماحة , أخصائى مختبر , مختبر

Hemoglobin (Hgb). The hemoglobin molecule fills up the RBCs. It carries oxygen & gives the RBCs its red color. The hemoglobin test measures the amount of hemoglobin in blood and is a good measure of the blood's ability to carry oxygen throughout the body

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